Detection of acetaminophen-induced liver damage by fluorescence bioimaging, serum biochemistry and histopathological examination
نویسندگان
چکیده
منابع مشابه
TRPM2 channels mediate acetaminophen-induced liver damage.
Acetaminophen (paracetamol) is the most frequently used analgesic and antipyretic drug available over the counter. At the same time, acetaminophen overdose is the most common cause of acute liver failure and the leading cause of chronic liver damage requiring liver transplantation in developed countries. Acetaminophen overdose causes a multitude of interrelated biochemical reactions in hepatocy...
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Reliable test systems to identify hepatotoxicity are essential to predict unexpected drug-related liver injury. Here we present a human ex-vivo liver model to investigate acetaminophen-induced liver injury. Human liver tissue was perfused over a 30 hour period with hourly sampling from the perfusate for measurement of general metabolism and clinical parameters. Liver function was assessed by cl...
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ژورنال
عنوان ژورنال: Journal of Biomedical Translational Research
سال: 2020
ISSN: 2508-1357,2508-139X
DOI: 10.12729/jbtr.2020.21.1.11